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Posts tagged with "Current Events"

  • Analytical Chemistry

    Antibody Tests for the Coronavirus

    Let’s talk antibodies. Mounting an antibody response is crucial for anyone to overcome a challenge from an infectious pathogen, and the immunity that can result is crucial for entire communities and populations. Determining who has such immunity is furthermore going to be crucial for us as we come out from under the current pandemic. If… Read More
  • Cardiovascular Disease

    Covid-19, Blood Pressure Medication, and Ibuprofen

    One of the questions that shows up often in the comments to the various Covid-19 posts here (especially this one) and very often in my own emails is whether people who are taking hypertension medications should alter their drug therapy based on the coronavirus epidemic. Most of those questions are specifically about ACE inhibitors (all… Read More
  • Clinical Trials

    Comparing HydroxyChloroquine Trials

    One minor side effect of the pandemic is that perhaps more people will learn about what drug research and clinical trials can really be like. Today’s example: we have a clinical trial of hydroxychloroquine from Wuhan that has just published on a preprint server. What’s good is that this one is blinded, randomized, and controlled… Read More
  • Clinical Trials

    More on Chloroquine/Azithromycin. And On Dr. Raoult.

    Dr. Didier Raoult of Marseilles and his co-workers have published another preprint on clinical results with the chloroquine/azithromycin combination that their earlier work has made famous. And I still don’t know what to think of it. This is going to be a long post on the whole issue, so if you don’t feel like reading… Read More
  • Current Events

    What the Coronavirus Proteins Are Targeting

    I wanted to mention this paper, which is one of the more comprehensive ones on the idea of repurposing existing drugs against the coronavirus. It’s a large multicenter team that clearly did a lot of very fast coordination to produce these results. What they’ve done is looked at the complete suite of proteins produced by… Read More
  • Clinical Trials

    The Latest Coronavirus Clinical Trials

    Time to catch up with the latest clinical news in the field. The big story this morning is apparently some real data out of a controlled trial of chloroquine from China. There have been anecdotal reports, but to the best of my knowledge we have seen no actual numbers. These are not exactly from the… Read More
  • Current Events

    Fogging the Air

    I wrote a post a while back on what I saw as “decontamination theater”: the shots (originally from China) of people fogging buildings and outdoor scenes with what was often described as some sort of disinfectant. As I wrote at the time, I was unaware of any antiviral sanitizing agent that was dispersed in this… Read More
  • Current Events

    Using the Time

    I’ve come to accept that the site is going to be pretty much all-corona-all-the-time during this crisis. I’ll try to do the occasional post on something else, but there’s so much news on the epidemic, so much (nearly involuntary!) interest and, not least, so much complete garbage information out there that I feel that those… Read More
  • Chemical News

    Chloroquine, Past and Present

    Now that chloroquine is in the news everywhere, I thought it might be interesting to have a closer look at the compound. The first part of this post will be chemistry-heavy, further down we’ll get into the pharmacology and medical uses. Chloroquine’s fame is as an antimalarial drug, and the history of antimalarials starts of… Read More
  • Current Events

    Coronavirus: Some Clinical Trial Data

    We’re starting to see some clinical trial data on possible Covid-19 therapies, specifically some of the ones mentioned in this earlier post on small-molecule approaches. First, the bad news (although I have to say it’s not unexpected). A trial of the lopinavir/ritonavir combination has shown no benefit. I say “not unexpected”… Read More
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