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Posts tagged with "Current Events"

  • Current Events

    Covid-19 Antibody Update for April 8

    Let’s do an update on the antibody situation in this epidemic (a bit of antibody/immunology background here if you would like some). The word is today that the CDC is starting several efforts to do antibody testing. One of these is to look at people (from areas that showed widespread cases of coronavirus) who never… Read More
  • Cardiovascular Disease

    Angiotensin and Coronavirus Infection: The Latest as of April 7

    I wrote here the other day on the recent recommendation that people taking either ACE (angiotensin-converting enzyme) inhibitors or ARBs (angiotensin receptor blockers) should not alter their treatment regimens because of the coronavirus outbreak. Some background on the angiotensin system is here, and here’s an open-access review for those wh… Read More
  • Current Events

    Hydroxychloroquine Update For April 6

    There’s a lot of news to catch up on, and to keep things straight I’ll divide the hydroxychloroquine part out into this post, and cover others in the next one. My previous reviews of the clinical data in this area are here. First up is this study from France. It’s another very small one, and… Read More
  • Analytical Chemistry

    Antibody Tests for the Coronavirus

    Let’s talk antibodies. Mounting an antibody response is crucial for anyone to overcome a challenge from an infectious pathogen, and the immunity that can result is crucial for entire communities and populations. Determining who has such immunity is furthermore going to be crucial for us as we come out from under the current pandemic. If… Read More
  • Cardiovascular Disease

    Covid-19, Blood Pressure Medication, and Ibuprofen

    One of the questions that shows up often in the comments to the various Covid-19 posts here (especially this one) and very often in my own emails is whether people who are taking hypertension medications should alter their drug therapy based on the coronavirus epidemic. Most of those questions are specifically about ACE inhibitors (all… Read More
  • Clinical Trials

    Comparing HydroxyChloroquine Trials

    One minor side effect of the pandemic is that perhaps more people will learn about what drug research and clinical trials can really be like. Today’s example: we have a clinical trial of hydroxychloroquine from Wuhan that has just published on a preprint server. What’s good is that this one is blinded, randomized, and controlled… Read More
  • Clinical Trials

    More on Hydroxychloroquine/Azithromycin. And On Dr. Raoult.

    Dr. Didier Raoult of Marseilles and his co-workers have published another preprint on clinical results with the chloroquine/azithromycin combination that their earlier work has made famous. And I still don’t know what to think of it. This is going to be a long post on the whole issue, so if you don’t feel like reading… Read More
  • Current Events

    What the Coronavirus Proteins Are Targeting

    I wanted to mention this paper, which is one of the more comprehensive ones on the idea of repurposing existing drugs against the coronavirus. It’s a large multicenter team that clearly did a lot of very fast coordination to produce these results. What they’ve done is looked at the complete suite of proteins produced by… Read More
  • Clinical Trials

    The Latest Coronavirus Clinical Trials

    Time to catch up with the latest clinical news in the field. The big story this morning is apparently some real data out of a controlled trial of chloroquine from China. There have been anecdotal reports, but to the best of my knowledge we have seen no actual numbers. These are not exactly from the… Read More
  • Current Events

    Fogging the Air

    I wrote a post a while back on what I saw as “decontamination theater”: the shots (originally from China) of people fogging buildings and outdoor scenes with what was often described as some sort of disinfectant. As I wrote at the time, I was unaware of any antiviral sanitizing agent that was dispersed in this… Read More