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Posts tagged with "Diabetes and Obesity"

  • Cardiovascular Disease

    Off Target? Which Target Did You Mean?

    Here’s a snapshot for you, to illustrate how little we know about what many of our compounds can do. I was browsing the latest issue of the British Journal of Pharmacology, which is one of many perfectly respectable journals in that field, and was struck by the table of contents. Here, for example, is a… Read More
  • Diabetes and Obesity

    More On Merck and Taranabant

    My piece on Merck last week seems to have touched a few nerves, if some of the comments and e-mails I’ve received are any sign. To clarify things: I agree that Merck is still doing some excellent science, as they always have. And they still have a lot of good people there, as they always… Read More
  • Diabetes and Obesity

    What You Become Known For

    A recent item from InVivoBlog about Merck which brought up some interesting points. They aren’t cheerful ones. The article is largely about Merck’s reputation, which has taken some dents in recent years, to put it lightly. The Vioxx debacle is the main reason for this, but the hits have kept on coming, such as the… Read More
  • Diabetes and Obesity

    Eat It, Breath It, Soak in It?

    After Pfizer’s Exubera inhaled-insulin product died so horribly in the market last year, the other companies working in the same space had to be worried. Lilly and Alkermes have had a long-running program, as has a smaller company called Mannkind. But recently, another contender, Novo Nordisk, has announced that they and partner Aradigm have deci… Read More
  • Biological News

    Avandia: Going Under for the Third Time?

    How many hits can a drug – or a whole class of drugs – take? Avandia (rosiglitazone) has been the subject of much wrangling about cardiovascular risk in its patient population of Type II diabetics. But there have also been scattered reports of increases in fractures among people taking it or Actos (pioglitazone), the other… Read More
  • "Me Too" Drugs

    Bad Luck For Novartis – And For Diabetics

    Novartis must wonder what they did to deserve this one. A few years ago, it looked as if they ruled the potentially lucrative world of dipeptidylylpeptidase-IV (DPP-IV) inhibitors for diabetes. (Note – name of enzyme corrected after brain hiccup – DBL). Novartis seemed to be the first big company to come up with good chemical… Read More
  • Diabetes and Obesity

    Depressing Figures for Acomplia

    Back in 2005, I worried about taking a new drug to market that had a completely new central nervous system mechanism: Acomplia (rimonabant). CNS makes me nervous. I used to work in the area, and I have a healthy respect for how little we know about it. So when you come in with something new… Read More
  • Business and Markets

    Surveying the Exubera Crater

    Pfizer has pulled the inhaled insulin Exubera from the market, and not because of the FDA, and not because of the lawyers. They’re giving up on it because they can’t take the pain any more. The company sold 12 million dollars worth of the stuff so far this year, a horrifyingly tiny amount. That represents… Read More
  • Biological News

    More Things Than Are Dreamt Of

    It’s useful to be reminded every so often of how much you don’t know. There’s a new paper in PNAS that’ll do that for a number of its readers. The authors report a new protein, one of the iron-sulfur binding ones. There are quite a few of these known already, so this wouldn’t be big… Read More
  • Business and Markets

    Buying What You Can’t Make? Or What?

    I didn’t note it at the time, but Amgen just recently finished buying a smaller company, Alantos. That cost them about $300 million, and for that money they got a diabetes drug in the clinic and a program generating compounds for arthritis and other diseases. Sound OK, eh? That’s the one-line executive summary right there… Read More