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Posts tagged with "Infectious Diseases"

  • Covid-19

    Coronavirus Vaccine Update, May 26

    We have a lot more vaccine news to catch up on, and I’ll use this as a new “frontrunning vaccine candidates” post, replacing this one (and updates therein) from about a month back. That one will give you some more general information on most of the projects below; if you haven’t read it, it’ll be a… Read More
  • Covid-19

    Hydroxychloroquine: Enough Already?

    At this point, it’s getting hard to see how the idea of a hydroxychloroquine (or hydroxychloroquine/azithromycin) therapy for coronavirus infection can be taken seriously. I reviewed some of the recent studies here, but missed a May 11 preprint from France that had claimed benefit for the combination. No matter, though: this was just withdraw… Read More
  • Covid-19

    There May Be a Unique Coronavirus Immune Response

    We’re starting to get a clearer picture of how the SARS-CoV-2 coronavirus works when it infects the body, and there are some surprises emerging. This new paper in Cell is an example (here’s a writeup on it at Stat). We already know the RNA sequence of the virus very well, naturally, and that’s allowing us… Read More
  • Clinical Trials

    First Results from Moderna’s Coronavirus Vaccine

    This morning brought news from Moderna of the very first human results from trials of their closely-watched mRNA vaccine candidate (mRNA-1273) against the coronavirus. Here’s Stat on the news, and here’s Endpts – the results can be summed up pretty quickly, because it’s all just at the press-release level to start with. The… Read More
  • Covid-19

    Criticism of the Oxford Coronavirus Vaccine

    This piece at Forbes by Bill Haseltine has set off a lot of comment – it’s a look at the Oxford group’s vaccine candidate as compared to the SinoVac candidate, and you may recall (background here) that these are the two teams that have separately reported that their vaccines appear to protect rhesus monkeys from… Read More
  • Covid-19

    Good News on the Human Immune Response to the Coronavirus

    One of the big (and so far unanswered) questions about the coronavirus epidemic is what kind of immunity people have after becoming infected. This is important for the idea of “re-infection” (is it even possible?) and of course for vaccine development. We’re getting more and more information in this area, though, and this new pape… Read More
  • Covid-19

    Monoclonal Antibodies and Vaccines: Q and A

    I’ve had a lot of questions from people about the prospects for monoclonal antibodies and vaccines against the coronavirus, and I thought that it might be helpful to answer them in this format. Let’s start the press conference! We’ll start with monoclonal antibodies. Why are you so optimistic that this technology will work? Two bi… Read More
  • Covid-19

    More Chinese Traditional Medicine, Unfortunately

    I mentioned the other day that what was reported as a hydroxychloroquine trial in China may well have been (or at least begun as) a trial of “traditional Chinese medicine” (TCM). It doesn’t take much digging to turn up a number of registered clinical trials for coronavirus therapy via TCM, actually. Here are a few… Read More
  • Covid-19

    What’s Up With Ivermectin?

    One of the small-molecule drugs that’s getting attention as a possible coronavirus treatment is Ivermectin, which is an interesting story from a couple of different directions. I’ve been getting some inquiries about it, so I thought it was time to have a look. Background on Ivermectin It’s part of a family of natural products call… Read More
  • Covid-19

    Mutations in the Coronavirus Spike Protein

    The last post talked about antibodies to the spike protein of the coronavirus, and one of the main things that everyone has to keep an eye on are the mutations in that area. That has implications for monoclonal antibody therapy, for vaccine production, and for the behavior of the coronavirus itself. Antibodies against the Spike… Read More
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