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Posts tagged with "Infectious Diseases"

  • Cancer

    Bacteria and Cancer: Another Connection

    Three months ago, I wrote about a report that some kinds of pancreatic cancer seem to be associated with particular infections, and wondered “How many similar stories are out there that we don’t know about yet?” Well, that didn’t take long to start being answered. This recent paper in Science (from a multicenter team: Dana- Read More
  • Drug Assays

    New Antibiotic Action

    I’m always happy to hear about new agents to treat gram-negative bacterial infections, especially after a stint working in antibiotic drug discovery myself. Seeing just how hard it is to kill these things did not improve my peace of mind about the problem of bacterial resistance, that’s for sure. So this paper caught my eye… Read More
  • Clinical Trials

    Not How You Speed the Process Up, Exactly

    Now, this truly does not sound like the way to run a clinical trial. Dr. William Halford of the Rational Vaccines company invited 20 patients to St. Kitts for a trial of a putative herpes vaccine. The consent forms explicitly stated that this was done to evade the jurisdiction of the US Food and Drug… Read More
  • Biological News

    Small Proteins: Into the Gap

    We medicinal chemists are used to thinking about small molecule drugs – it’s what we do. And we’re also comfortable with having a category in our worldview that we assign to “biologics” – proteins, mostly, many of them antibodies, which can also be extremely therapeutically effective under the right conditions. B… Read More
  • Cancer

    Bacteria Can Make Tumors Worse

    Since the topic of bacteria effects on human disease came up here just the other day, I wanted to point out a new article that comes at this idea from a different direction. This research got going when cells from pancreatic and colon tumor samples were co-cultured with human dermal fibroblasts. The cancer cell lines… Read More
  • Infectious Diseases

    Microbiome Connections to Disease Get Stronger

    A fair amount of what you read about the human microbiome is hype. There’s no way around it. It’s quite difficult to study this area in a meaningful, reproducible way, and even the best work in the area can only go so far, as things stand now. When differences in (say) gut flora are actually… Read More
  • Chemical Biology

    Tagging Fungi For Destruction

    Fungal infections can be very bad news when they go beyond the get-something-from-the-drugstore stage. That fact that a drug as rough as amphotericin B is still in use is evidence enough of that. There’s definitely a need for new ideas in the antifungal area, but drug discovery there has been tough. This new paper, though… Read More
  • Infectious Diseases

    More Bacterial Targets Than You Know

    Do you want to find new drugs treat human bacterial infections? (If you don’t, you’d better hope that someone else does!) The standard view in the field has long been that you have to target some essential pathway in those bacteria, one that doesn’t have a counterpart in human biology (or whose sequence and structure… Read More
  • Drug Industry History

    Where MRSA Came From

    OK, everyone recognizes the problem that we face with drug-resistant bacteria. MRSA (methicillin-resistant Staphylococcus aureus) is the most well-known variety, and it’s bad news. Penicillin was introduced in the 1940s, and methicillin was brought to market in 1959, largely because so many infections were becoming resistant to penicillin by… Read More
  • Drug Development

    A Long Journey to the Capsid

    There’s a fine article at C&E News on Gilead’s capsid inhibitor for HIV. For those not into virology, the capsid is the protein coat that viruses have – it’s their armor, more or less, and disrupting its formation should be a large problem for them. But finding compounds that accomplish that is a large problem… Read More
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