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Posts tagged with "Infectious Diseases"

  • Clinical Trials

    First Results from Moderna’s Coronavirus Vaccine

    This morning brought news from Moderna of the very first human results from trials of their closely-watched mRNA vaccine candidate (mRNA-1273) against the coronavirus. Here’s Stat on the news, and here’s Endpts – the results can be summed up pretty quickly, because it’s all just at the press-release level to start with. The… Read More
  • Covid-19

    Criticism of the Oxford Coronavirus Vaccine

    This piece at Forbes by Bill Haseltine has set off a lot of comment – it’s a look at the Oxford group’s vaccine candidate as compared to the SinoVac candidate, and you may recall (background here) that these are the two teams that have separately reported that their vaccines appear to protect rhesus monkeys from… Read More
  • Covid-19

    Good News on the Human Immune Response to the Coronavirus

    One of the big (and so far unanswered) questions about the coronavirus epidemic is what kind of immunity people have after becoming infected. This is important for the idea of “re-infection” (is it even possible?) and of course for vaccine development. We’re getting more and more information in this area, though, and this new pape… Read More
  • Covid-19

    Monoclonal Antibodies and Vaccines: Q and A

    I’ve had a lot of questions from people about the prospects for monoclonal antibodies and vaccines against the coronavirus, and I thought that it might be helpful to answer them in this format. Let’s start the press conference! We’ll start with monoclonal antibodies. Why are you so optimistic that this technology will work? Two bi… Read More
  • Covid-19

    More Chinese Traditional Medicine, Unfortunately

    I mentioned the other day that what was reported as a hydroxychloroquine trial in China may well have been (or at least begun as) a trial of “traditional Chinese medicine” (TCM). It doesn’t take much digging to turn up a number of registered clinical trials for coronavirus therapy via TCM, actually. Here are a few… Read More
  • Covid-19

    What’s Up With Ivermectin?

    One of the small-molecule drugs that’s getting attention as a possible coronavirus treatment is Ivermectin, which is an interesting story from a couple of different directions. I’ve been getting some inquiries about it, so I thought it was time to have a look. Background on Ivermectin It’s part of a family of natural products call… Read More
  • Covid-19

    Mutations in the Coronavirus Spike Protein

    The last post talked about antibodies to the spike protein of the coronavirus, and one of the main things that everyone has to keep an eye on are the mutations in that area. That has implications for monoclonal antibody therapy, for vaccine production, and for the behavior of the coronavirus itself. Antibodies against the Spike… Read More
  • Clinical Trials

    Hydroxychloroquine Update, May 4

    It’s been some days since I posted on the hydroxychloroquine situation versus the coronavirus epidemic, but I have been getting plenty of inquiries. So let’s have a look at what’s been going on! Several people have pointed out this new preprint, a retrospective look at 568 patients in Wuhan. Update: there is something odd about… Read More
  • Clinical Trials

    About Remdesivir and About “Game-Changers”

    We’ve had several releases of remdesivir data, and this was not exactly one of those controlled-release formulations. No, this was more in the “chaotic mess” category, with news items coming from several sources with partial information. I decided not to blog on it until the loud banging noises stopped, and I’m glad I did, s… Read More
  • Covid-19

    Monoclonal Antibodies for the Coronavirus (Updated May 5th)

    Antibodies as a therapy Let’s have a look at what is (in my opinion) probably our best shot at a reasonably short-term targeted therapy against the COVID-19 epidemic: the possibility of using monoclonal antibodies. These can be developed more quickly than vaccines, and a lot more quickly than a new targeted small-molecule antiviral. Like ever… Read More