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Posts tagged with "Life in the Drug Labs"

  • Drug Development

    How to Be a Good Medicinal Chemist

    Longtime medicinal chemist Mark Murcko has a Perspective article out in J. Med. Chem. on “What Makes a Great Medicinal Chemist“. As he makes clear from the beginning, if you’ve been doing this stuff for a while, you’ve likely heard many of these recommendations before. But it’s useful for people starting out, and it… Read More
  • Drug Assays

    Thoughts on Compound Collections

    I’ve recently had similar questions from two different people (on two different coasts) about screening collections and compound libraries, so it seems like it could be a topic of interest. So far I have yet to come across a drug discovery organization that really thinks that its compound libraries are what they should be – Read More
  • Drug Assays

    One Way to Find Out

    Here’s a thing about research (and drug discovery in particular) that makes it a bit different from many other occupations: you can go for extended periods without even being sure that you’re doing what you’re supposed to be doing. This thought came to mind yesterday when (on Twitter) Ash Jogalekar quoted a biotech veteran as… Read More
  • Life in the Drug Labs

    Chemicals, Shelves and Shelves of Them

    My mention yesterday of the number of starting materials needed for drug synthesis prompted a reader outside the industry to ask just how many I might be talking about, and how these things are managed. I looked over the paper being discussed, just for an example, and for its three drug syntheses it needed a… Read More
  • Life in the Drug Labs

    Now, Let’s See. . .

    As you can tell, it’s been quiet around here! I’m living up to the recipes I’ve published on the blog this time of year, though – I made the chicken pot pie last night, and it was a good night to stay indoors and eat it, since it got down to -4F around here. Soon… Read More
  • Chemical News

    Extraction and Salting-Out

    I really enjoyed this paper, because it goes into detail on a technique that organic bench chemists the world over have all used at some point: “salting out”. I’ll go into some background for the nonchemists for a few paragraphs and then return to the paper itself, which all working organic chemists should have a… Read More
  • Drug Development

    Cutting (And Re-Cutting) the Research Pie

    Here’s something that goes on inside almost every biopharma research organization, but always happens behind the scenes if you’re not right there at the meetings: resource allocation for projects. That “almost” is in there because the smallest companies don’t have this problem in the same way, since they tend to have o… Read More
  • Life in the Drug Labs

    Pyridine Doesn’t Do What You Think It Does

    OK, this is not exactly a time-sensitive issue, but since I took a crack at one of the most prominent toxicology myths in the biology labs (ethidium bromide is not really all that bad, in case you missed it), I figured I should do the same for one of the persistent myths on the organic… Read More
  • Life in the Drug Labs

    Back To It

    Welcome to 2017, and as usual, it seems like a number for a year in a science-fiction story rather than on everyone’s calendar. I console myself with realizing that I’ve been thinking that way since about 1980, which probably comes from reading a heck of a lot of old science fiction stories while growing up… Read More
  • Chemical News

    Chemical Storage, Good and Not So Good

    Back to science! I will admit that my Twitter feed is going to be rather more politicized than usual for some time to come, but this is not a political site, and thank God for that. I have to say, it certainly brings in the comments and the traffic, but that’s not my goal in life. Read More