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Posts tagged with "Life in the Drug Labs"

  • Life in the Drug Labs

    Doubleplusgood CorporateSpeak

    It was back in late June that Bristol Myers Squibb announced that they were closing their Wallingford, CT site and relocating employees. Some employees. You might have thought that people would know their fate by now, but you’d be mistaken. Many are just finding out if they’re going to be able to apply for a… Read More
  • Drug Industry History

    That One Big Answer

    This post by Wavefunction on the foxes-and-hedgehogs split in drug discovery is well worth reading. You may recall, via Isaiah Berlin and Archilochus, that a fox knows many things, while a hedgehog knows one big thing. Here’s how that can apply to the drug R&D business: Now drug discovery should be the poster boy for… Read More
  • Life in the Drug Labs

    No Water, No Problem

    I have some colleagues who are evaluating these “no flowing water” condensers for reactions. Anyone out there have any experience with them? It’s for sure that there have been a lot of lab floods over the years from condenser hoses that pop off, and the expense of all that water can be a problem, too. Read More
  • Life in the Drug Labs

    Voodoo Nominations

    I’d like to open up the floor for nominations for the Blackest Art in All of Chemistry. And my candidate is a strong, strong contender: crystallization. When you go into a protein crystallography lab and see stack after stack after stack of plastic trays, each containing scores of different little wells, each with a slight… Read More
  • Life in the Drug Labs

    Solvents and More Solvents

    I’ve been doing a solvent screen on a particular reaction recently, and it has me thinking about the number of times I’ve done that sort of thing before. Synthetic organic chemists spend most of their time using relatively few reaction solvents – there’s a lot of dichloromethane, a lot of tetrahydrofuran (and some diethyl et… Read More
  • Life in the Drug Labs

    Chemistry Labs Through the Years

    I have a review out today in Nature on a good history of chemical laboratories, The Matter Factory. Now that most chemistry labs look more or less the same, it was interesting to go back and see how we ended up this way, and what else had been tried. I liked the book; it really… Read More
  • Life in the Drug Labs

    Asking the Employees

    Every company that I’ve ever worked for has said that they want suggestions from the employees – some of them have been serious, and others were saying it because that’s the sort of thing you’re supposed to say. There are, naturally, all sorts of levels to consider. Some suggestions are small and easily implemented (or… Read More
  • Drug Development

    What Are the Odds of Finding a Drug (And How Do You Stand Them?)

    Lisa Jarvis of C&E News asked a question on Twitter that’s worth some back-of-the-envelope calculation: what are the odds of a medicinal chemist discovering a drug during his or her career? And (I checked) she means “personally synthesizing the compound that makes it to market”. My own hand-waving guesstimate of an upper boun… Read More
  • Drug Industry History

    How Many Chemists Have You Seen on a Team?

    I’m traveling today to give a talk (at this regional meeting of the AAPS), so I don’t have my usual train commute wherein to do the morning blog post. So I wanted to set off a bit of discussion instead. I had an email from someone whose boss was at Merck during the Ed Skolnik… Read More
  • Chemical News

    Phosphorus And Me. Or Maybe You First.

    A commenter mentioned fosfomycin in this morning’s post, which prompts me to put its structure up for those who don’t know the compound. Now that’s a strange little beast. It’s a natural product, as you might well think – who’s going to make that on purpose? And it’s also a pretty decent antibacterial, as a… Read More