Derek Lowe's commentary on drug discovery and the pharma industry. An editorially independent blog from the publishers of Science Translational Medicine. All content is Derek’s own, and he does not in any way speak for his employer.

By Derek Lowe

Posts tagged with "Natural Products"

• Analytical Chemistry

  Natural Product Artifacts

  29 May, 2019

  Like many organic chemists, I find natural products very interesting, since their structures are often things that I would never imagine making (and in some cases have trouble imagining how to make at all!) But there’s a feature of the literature in that area that not everyone appreciates: the fact that a reasonable number of… Read More

• Chemical News

  Modifying Natural Products

  1 May, 2019

  Here’s a thorough review of a topic that combines complex drug development issues with complex chemistry: trying to optimize the structures of natural products so that they can be more effective drugs. There are detailed looks at examples like the tetracyclines, the polyene macrolides, pactamycin, geldanamycin, and the thiostrepton-like pepti… Read More

• Chemical News

  New Chemistry, Making New Things

  19 March, 2019

  In a perverse way, I’m enjoying how modern organic synthesis is upsetting the classic undergraduate sort of test-question syntheses. You know – Grignards, ester condensations, oxidation and reduction of carbonyls, Wittigs, Sandmeyer reactions, Friedel-Crafts, good ol’ hammer-and-tongs bond formation. I had sophomore organic back i… Read More

• "Me Too" Drugs

  Proteasome Inhibitors, Refined

  27 February, 2019

  The proteasome is quite the structure. It is the shredding unit of the cell, where no-longer-needed proteins go to be ripped down to their components for recycling, and it’s become a more and more important part of drug discovery over the years. For one thing, all this fashionable targeted protein degradation work is about sending… Read More

• Biological News

  Bacteria and Depression: Something to Test

  17 January, 2019

  Microbiome, microbiome – you haven’t been able to turn around in this business the last few years without hitting some sort of story about the microbiome. It’s easy to roll your eyes and decide that it’s all hype, but that’s the thing: it really is important. It can’t be dismissed just because we don’t unde… Read More

• Clinical Trials

  Artemisia Comes Through Again

  9 January, 2019

  Here’s an unusual twist for you. Many readers will be familiar – to their regret, most likely – with the story of T*ring Pharmaceuticals (name redacted slightly in order to not defame a great scientist whose name was tacked on to this outfit for no reason other than advertising). Their first idea was to go… Read More

• Natural Products

  A Slow, Slow Retraction

  10 July, 2018

  Some readers may recall this post from 2015, which details problems with a natural product isolation paper in PLOS ONE. The compound, named Xinghaiamine A by the authors, was. . .well, let’s say extremely unlikely, and I think anyone who looks at the structure in that earlier post will agree. And that spans several levels… Read More

• Chemical News

  Stop Ignoring the Sugars!

  7 May, 2018

  This paper (from two groups at Yale’s chemistry department) addresses several important things that fall into the “important irritants” category in synthesis and molecular biology – or maybe that should be “irritatingly important”. We spend a lot of time thinking about proteins in terms of their primary sequence… Read More

• Chemical News

  The Thoughts of George Whitesides, Part I

  12 April, 2018

  A number of readers have mentioned this new paper by George Whitesides on organic synthesis. I can state as a fact that the first time I heard a joking reference to his attitude towards traditional synthetic organic chemistry was in the summer of 1983, so it’s not like he’s been keeping his thoughts bottled up. Read More

• Natural Products

  Scooped, I Suppose the Word Is

  17 January, 2018

  Via Retraction Watch, here’s a situation that I don’t recall seeing before: a group at Foshan University in China published a paper in the journal Natural Product Research on the crystal structure of aspergicine. Here’s the original abstract in PubMed – their work prompted them to revise their previously published structure… Read More