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Posts tagged with "Natural Products"

  • Biological News

    More on Warp Drive Bio and Cryptic Natural Products

    At C&E News, Lisa Jarvis has an excellent writeup on Warp Drive Bio and the whole idea of “cryptic natural products” (last blogged on here). As the piece makes clear, not everyone even is buying into the idea that there’s a lot of useful-but-little-expressed natural product chemical matter out there, but since there could be… Read More
  • Chemical News

    Ingenol: A Walk In The Park

    The Baran group at Scripps has a whopper of a total synthesis out in Science. They have a route to the natural product ingenol, which is isolated from a Euphorbia species, a genus that produces a lot of funky diterpenoids. A synthetic ester of the compound as recently been approved to treat actinic keratosis, a… Read More
  • Biological News

    More From Warp Drive Bio (And Less From Aileron?)

    There hasn’t been much news about Warp Drive Bio since their founding. And that founding was a bit of an unusual event all by itself, since the company was born with a Sanofi deal already in place (and an agreement for them to buy the company if targets were met). But now things seem to… Read More
  • Drug Assays

    Protein-Protein Compounds – The Flip Side

    The topic of protein-protein inhibitor compounds has come up around here several times. It’s the classic “undruggable” target, although that adjective isn’t quite accurate. Let’s leave it at “definitely harder than the usual stuff”; no one could argue with that. But there’s a flip side to this area th… Read More
  • Analytical Chemistry

    Picking Out Incorrect Natural Products

    Once in a while, you see people who’ve gone to the trouble of synthesizing a natural product, only to find that its structure had been incorrectly assigned. (Back in the days when structure elucidation was much harder, R. B. Woodward had this on his list of reasons to do total synthesis, although it wasn’t number… Read More
  • Chemical Biology

    Forcing Fungi to Make Stranger Compounds

    Natural products come up around here fairly often, as sources of chemical diversity and inspiration. Here’s a paper that combines them with another topic (epigenetics) that’s been popular around here as well, even if there’s some disagreement about what the word means. A group of Japanese researchers were looking at the natural pr… Read More
  • Chemical News

    A Total Synthesis Archive

    For those who are into total synthesis of natural products, Arash Soheili has a Twitter account (Total_Synthesis) that keeps track of all the reports in the major journals. He’s emailed me with a link to a searchable database of all these, which brings a lot of not-so-easily-collated information together into one place. Have a look! Read More
  • Chemical News

    Natural Product Fragments: Get Rid of the Ugly Ones Now

    Here’s a paper at the intersection of two useful areas: natural products and fragments. Dan Erlanson over at Practical Fragments has a good, detailed look at the the work. What the authors have done is tried to break down known natural product structures into fragment-sized pieces, and cluster those together for guidance in assembling new… Read More
  • Chemical News

    Anyone Still Swimming in the Chiral Pool?

    My grad school work was chiral-pool synthesis; trying to make a complex natural product from carbohydrate starting materials. There was quite a bit of that around in those days, but you have to wonder about its place in the world by now. It’s true that everyone likes to be able to buy their chiral centers… Read More
  • Chemical News

    Natural Products Continue to Weird Me Out

    Here’s a funny-looking compound for you – Ivorenolide A, isolated from mahogany tree bark, it has an 18-membered ring with conjugated acetylenes in it. That makes the 3-D structure quite weird; it’s nearly flat. And it has biological activity, too (immunosuppression, as measured by T-cell and B-cell proliferation assay in vitro).… Read More
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