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Posts tagged with "The Central Nervous System"

  • Biological News

    Human Brains and Mouse Brains: So Similar, So Different

    Well, it’s inadvertently been sort of a Neuroscience Week here. This latest paper is a very interesting addition to the field indeed, just out from a very large team centered at the Allen Institute, where some rather large-scale work in the field has been done in the past. This one continues their tradition: it’s a… Read More
  • Biological News

    Unfolding the Unfolded Protein Response.

    When you look closely at cellular biochemistry, what you see are a lot of amazing processes that are surrounded by amazing amounts of redundancy, backups, patches, and accumulated tweaks and fixes. That’s evolution for you; these things have been piling up for a billion years or two, and we’re all the descendants of the critters… Read More
  • Drug Assays

    Phenotypic Neuroscience

    This is a good review from AstraZeneca scientists on phenotypic screening in neurodegenerative disease (by which one means Parkinson’s, Huntington’s, frontotemporal dementia, Lewy body dementia, and of course Alzheimer’s). And it’ll serve as a good intro to the challenges in these two fields in general, and to why they inter… Read More
  • Biological News

    A Condensate-Modifying Compound, Put to the Test

    I’ve written several times here about phase-separated condensates in cells, but now comes a rarity: a paper with some evidence for a therapeutic application. Everyone in the field has been thinking along such lines, naturally, but this is the first small-molecule screen that I’ve seen that tries to tie modifying condensate behavior in t… Read More
  • Alzheimer's Disease

    A Missed Alzheimer’s Opportunity? Not So Much

    The Washington Post made quite a splash with this story about Pfizer, Enbrel (etanercept), and Alzheimer’s disease. There’s already been a lot of comment about it yesterday on Twitter and in some other venues, but I thought it might be useful to try to sum things up in an easily accessible place. Here we go: Read More
  • Biological News

    The Secret Life of the Insulin Receptor

    You’d think that we would understand the workings of something like the insulin receptor by now, wouldn’t you? I worked in the metabolic disease area for several years, and I can give you the canonical version of its activities as it relates to insulin levels and glucose handling out in the canonical tissues (muscle, adipose). Read More
  • Animal Testing

    Autism Mouse Models for the Microbiome?

    Many readers will have seen the paper that just came out on a possible mouse-model demonstration of a connection between autism and the gut microbiome. It’s certainly generated a lot of headlines, and its very title guaranteed that it would: “Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice“.… Read More
  • Aging and Lifespan

    VCAM1 As a Player in the Aging Brain

    Possible intervention targets for age-related degeneration are always welcome, particularly when they come bearing experimental evidence, and even more so when they relate to the central nervous system. That’s the case with this new paper, from a multicenter team led out of Stanford. Interestingly, this also ties in with the well-publicized … Read More
  • Pharmacokinetics

    There Is No “Depression Gene”

    I wrote a couple of years ago about the long-running study of mutations in a serotonin transporter gene. Over the years, polymorphism in the gene have been correlated with all sorts of human behavior and psychiatry, in keeping with the importance of serotonin signaling in human cognition. Depression, anxiety, that whole end of human behavior… Read More
  • Animal Testing

    Enough With the Mouse Behavioral Models?

    This piece in STAT is well worth a read. The author, Adam Rosenberg of Rodin Therapeutics, is ready to ditch rodent-centric models for human CNS disease, and I can see where he’s coming from. I’ve often said that when I think back on my Alzheimer’s and schizophrenia drug discovery days (back when I was first… Read More
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