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Posts tagged with "Uncategorized"

  • Hard Thinking About Protein Degradation and Bifunctional Molecules

    This paper (open access) is not going to be to everyone’s taste, but the people who are working in its area – and there’s an ever-increasing number of them – will want to read it closely. It’s a close look at the red-hot fields of targeted protein degradation and “molecular glues”, and for those who aren&# Read More
  • Covid-19

    Vaccine Efficacy Questions

    Next up on the vaccine news front are some concerns about efficacy. In a very surprising statement, Gao Fu (the head of the Chinese Center for Disease Control and Prevention) said at a conference in Chengdu over the weekend that that the protection figures of the Chinese vaccines are “not high”. He called for research… Read More
  • Molnupiravir: Last of the Small-Molecule Coronavirus Hopes?

    Update: the day after this post appeared, Merck and Ridgeback announced some preliminary positive data on reduction of viral load in treated patients. The full Phase II data should be coming soon? A lot of people have been wondering about what’s up with a small-molecular antiviral compound that’s been in the news on and off… Read More
  • How to Administer RNA – And How to Do It Again

    As the world knows, the mRNA vaccines for the coronavirus are proving to be very effective. That’s welcome news for the obvious pandemic reasons, but it’s also welcome validation for a technique that’s been in the works for many years now. I’ll take a moment to re-emphasize how fortunate we are that so much of… Read More
  • Early March Vaccine Thoughts

    Some thoughts about the current vaccine trials and data, some of which are probably obvious, but which might be worth bringing together: First, as many have been mentioning, it’s tempting but quite difficult to compare the vaccines (and vaccine candidates) head-to-head by looking at their phase III data. I would only feel safe doing this… Read More
  • A Malaria Vaccine Candidate

    This story has been passed around a lot the last few days, and I’ve had several people ask me what I’ve thought of it. It’s on a really interesting possibility for a malaria vaccine, and part of the narrative hook is that it’s using mRNA technology, which is about as attention-getting a topic these days… Read More
  • That Kodak Deal

    Many people have been wondering what’s going on with the announcement by the Trump administration that Kodak has been contracted to produce pharmaceutical APIs here in the US. Let’s line up some of the public statements about all this first, and then take a closer look. Here’s the press release from Kodak after signing a “L… Read More
  • Vaccine Derangement

    I’m working on a new vaccine roundup post for tomorrow – it’s been a couple of weeks, and there’s a lot of news to catch up on. But first off, a comment on vaccines in general. As the prospect of these become more real in the public mind, I’m noticing more and more anti-vaccine takes, from… Read More
  • Thoughts on Antibody Persistence and the Pandemic

    The fundamental challenge of dealing with this pandemic is uncertainty. There are just too many important things that we don’t know – and what’s more, they aren’t easy to find out, either. We’ve seen that with the waves of optimism and pessimism about various therapies, just to pick one. As everyone has been learning … Read More
  • Another Set of Coronavirus Vaccine Candidates

    I surveyed the coronavirus vaccine landscape in this post, and then detailed some of the larger efforts in the field here (several updates have been added to that one since its initial posting). Now it’s time to look at several programs that aren’t in either of those, but still have plenty of serious science behind… Read More