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Posts tagged with "Uncategorized"

  • Only Two Out of Ten Drugs? Really?

    You sometimes see the claim that only twenty per cent of drugs that make it to the market actually recoup their development costs. Here’s a recent sighting, and there are more. This figure has never seemed quite right to me, though. There certainly are drugs that don’t earn it back – of that there can… Read More
  • Making Cells Do Your Work (Also, The Revenge of the Yeast)

    Enzymes do things we can’t do. That’s one of the facts of life in organic synthesis, and it’s likely to be true for quite a while. (We can do things that enzymes can’t do, to be sure, but in many cases that’s probably because enzymes have never yet seen a need to do them). Cells, most… Read More
  • Scanning Through Sulfonyl Fluorides

    Last year I mentioned the “sulfur-fluoride exchange” reactions developed by the Sharpless group at Scripps, which is both an addition to the list of click chemistry reactions and a very fast entry into several underexplored compound classes. Now I see that they’re leveraging this technique (along with Peng Wu’s group there)… Read More
  • Book Recommendations

    Book Recommendations 2015: Medicinal Chemistry Books

    So it’s true that they’re not everyone’s Christmas present, but I wanted to do my yearly roundup of books on medicinal chemistry and drug discovery. This list builds on last year’s recommendations, with updated editions of some titles, and adds a number of suggestions from readers. A relatively recent (2011) history of our w… Read More
  • What to Do About Turing (And the Others)

    In the post just before this one, I’ve outlined the situation with Turing Pharmaceuticals and their strategy of gigantic price increases. As the links there show, however, they’re not alone. Several other companies have the same idea: find a small drug, for a small population, that’s not selling for much, and ram the price up… Read More
  • Life in the Drug Labs

    No Water, No Problem

    I have some colleagues who are evaluating these “no flowing water” condensers for reactions. Anyone out there have any experience with them? It’s for sure that there have been a lot of lab floods over the years from condenser hoses that pop off, and the expense of all that water can be a problem, too. Read More
  • Analytical Chemistry

    Asphalt, Up Close and Personal

    I wrote not long ago about another use of atomic force microscopy images to determine chemical structures, and now here’s another paper on the same general topic. Pretty soon, this is going to become too common to note, and structure determination will have changed forever (once again!) Shown are some asphaltenes – and if you’ve… Read More
  • Business and Markets

    What Became of Cubist

    Cubist was one of the pure-play antibiotic companies, until Merck bought them in late 2014. And once they’d done that, they wasted no time at all making their rationale clear. They wanted Cubist’s late-stage clinical assets, and they had no use whatsoever for Cubist’s R&D people, whom they quickly fired en masse. Treating the… Read More
  • The Least Useful Element For Organic Chemistry?

    I’ve recently been adding to my list of elements I’ve worked with, which is a nice effect of my current side project. I’ll do an updated post once I total things up; there are some more on order, but I can tell you that I’ve already checked off a number of the ones mentioned in… Read More
  • Chemical News

    Asking the Employees

    Every company that I’ve ever worked for has said that they want suggestions from the employees – some of them have been serious, and others were saying it because that’s the sort of thing you’re supposed to say. There are, naturally, all sorts of levels to consider. Some suggestions are small and easily implemented (or… Read More