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Derek Lowe

By Derek Lowe

  • Snake Oil

    Varieties of Nonsense

    Here’s a bulletin that should surprise no one: there’s a lot of wrong information out there. And by “out there” I mean not only the scientific literature, of course, although there’s certainly plenty of that. But there’s a taxonomy of wrongness, and the biggest split comes between “honestly intended but mis… Read More

  • The Scientific Literature

    Plan S Is Still Coming

    It’s been a few months since I wrote about “Plan S”, the far-reaching effort by several European governments to require open-access publication for scientific projects that they fund. Since this was announced last fall, the whole scientific publishing world has been trying to deal with the potential consequences, authors and publi… Read More

  • Animal Testing

    Autism Mouse Models for the Microbiome?

    Many readers will have seen the paper that just came out on a possible mouse-model demonstration of a connection between autism and the gut microbiome. It’s certainly generated a lot of headlines, and its very title guaranteed that it would: “Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice“.… Read More

  • Chemical News

    The Cyclofluidic Story

    The recent post here on automation in chemistry (especially medicinal chemistry) is a good intro for this paper in ACS Med. Chem. Letters. It’s from David Parry, who led Cyclofluidic, and I’ve blogged about them a few times over the years. That was a company formed in 2008 in the UK to try to develop… Read More

  • Analytical Chemistry

    Natural Product Artifacts

    Like many organic chemists, I find natural products very interesting, since their structures are often things that I would never imagine making (and in some cases have trouble imagining how to make at all!) But there’s a feature of the literature in that area that not everyone appreciates: the fact that a reasonable number of… Read More

  • Academia (vs. Industry)

    Where Drugs Come From: A Comprehensive Look

    This is a solid article by Jeffrey Flier (open-access in the Journal of Clinical Investigation) on the roles of academia and industry in drug discovery. Which is a topic that refuses to go away. I am prepared to swear that before starting this blog I had no idea of how many people are convinced that… Read More

  • Blog Housekeeping

    Travel

    I’m traveling for the next couple of days, so regular blog posting will resume on Monday. See everyone then! Read More

  • Biological News

    Antibody Design, Publicly Challenged

    Comes now some rather disturbing news in the antibody field. These things are extremely important, both as therapeutics and as research reagents, and developing them for either purpose is no stroll down the garden walk. There are a number of techniques for raising and producing antibodies (see that first link), but they all have their… Read More

  • Life in the Drug Labs

    The Killer Experiment

    Bruce Booth has some thoughts here on a recent Harvard Business Review piece on startups, but don’t let the fact that it’s from HBR put you off from taking a look. The original article is focused on innovation in general, but Booth ties it more directly to biopharma culture, and his advice certainly looks sound… Read More

  • Analytical Chemistry

    Absolute Configuration With Electrons

    When I first wrote about small-molecule structures obtained by microED (electron diffraction), I wondered if there were some way to get absolute stereochemistry out of the data (as you can with X-ray diffraction under the right conditions). Several groups have been working on just that problem, and this new paper now shows that it can… Read More
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